S is probably the worst supported scale out there........but if you have the space for a layout, and you enjoy scratchbuilding, go for it!
It's a neat scale, but as MRLdave wrote, you'll need to carefully research S Scale resources before committing to it. I used to enjoy seeing South Carolina's Piedmont S Scalers run their layout at local shows, but with most of the club's members north of 70 years old, the club recently set up one last time and will be seen no more. Kind of sad, but in their case, younger modelers weren't drawn to S Scale. Be advised that Lionel now owns the American Flyer brand and seems to support it well [ http://www.lionel.com/brands/american-flyer ]
Since your avatar is B&O and your handle refers to Reading's T-1, I doubt you're anywhere close to coastal Mississippi. However, IF you're ever down here, drop by the Mississippi Coast Model Railroad Museum in Gulfport. One member is displaying and operating a whole mess of S equipment.
Des Plaines Hobbies in Chicago is pretty much the hottest spot in the USA for supplies. The original owner has passed away and was dedicated to S scale and the new owner of the shop is committed to expanding S scale.
Oddly enough, and I know I'm resurrecting an older thread here, there's a flea market/antique store not too far from where I live which has a number of S-scale cars; some are by Flyer; others, Lionel; but none are in pristine condition. Then again, they're only a few dollars apiece. I'd buy them myself if I had the space and the funds!
There is an S scale club near by I will check out in the spring. Couldn't find it before. I did work with them when I lived in Milwaukee in the '70s.
Not sure if they're still in business--I haven't bought a copy of RMC or MR in years--but there at least used to be a publication called "The S Gaugian" or something like that. Maybe Heimburger House had or still has some print material. The greatest challenge for S scale/gauge is the price, especially for motive power. There was also a hobby shop east of Des Moines, IA (Colfax, I think), housed in one or two old passenger cars. Back when I was 4, Mom and Dad got an American Flyer set with three wooden passenger cars and some kind of engine; I honestly don't remember. Anyway, those cars were rugged but eventually snuck out of my room when I wasn't looking. This hobby shop had the exact same style of "Wild West" wooden cars; a coach, a combine, and I think a baggage car but after all these years I'm not sure. Anyway, when I saw those cars, it brought tears to my eyes, that a gift of love from so many years ago was something I could still remember.
